Meseclazone, W-2395
Chemical Name: 7-Chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:By cyclization of 5-chlorosalicylhidroxamic acid (I) with 3-methylacrolein (II) by means of HCl in ethanol or acetic acid that gives 6-chloro-2-(2-chloropropyl)-2,3-dihydro-3-hydroxy-4H-1,3-benzoxazin-4-one (III),which is finally cyclized again with aqueous NaOH,or sodium methoxide in methanol
📌 参考资料/链接：
参考文献标题:Meseclazone
文献作者:Casta馿r,J.; Arrigoni,Martelli,E.
参考来源:Drugs Fut 1977,2(6),380
📄 详细内容
合成路线:By cyclization of 5-chlorosalicylhidroxamic acid (I) with 3-methylacrolein (II) by means of HCl in ethanol or acetic acid that gives 6-chloro-2-(2-chloropropyl)-2,3-dihydro-3-hydroxy-4H-1,3-benzoxazin-4-one (III),which is finally cyclized again with aqueous NaOH,or sodium methoxide in methanol
参考文献标题:
文献作者:Reisner,D.B.; et al.(Carter-Wallace,Inc.)
参考来源:DE 2010418; US 3598814