LASSBio-468

Chemical Name: 2-[4-(Thiomorpholin-4-ylsulfonyl)phenyl]-2,3-dihydro-1H-isoindole-1,3-dione
项目整合开发状态: Preclinical
项目研究机构: CNRS (Originator), LASSBio (Originator)
合成路线:The condensation of phthalic anhydride (I) with aniline (II) in refluxing HOAc produced N-phenyl phthalimide (III).Aromatic sulfonation of (III) with chlorosulfonic acid in the presence of PCl5 afforded the sulfonyl chloride (IV).This was finally condensed with thiomorpholine (V) to furnish the target sulfonamide.