新产品编号:2068183
Chemical Name: 3-Chloro-N-[5(S*)-hydroxy-1(S*),3,3-trimethylcyclohexylmethyl]benzenecarbothioamide
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The condensation of the known amine (Ia-b) with (3-chloro-thiobenzoylsulfanyl)acetic acid (II) took place with thioester cleavage to produce a mixture of diastereomeric thioamides (III) and (IV),from which the title trans-isomer (III) was isolated by chromatography.
📌 参考资料/链接：
参考文献标题:An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology
文献作者:Deshpande,M.S.; Wei,J.; Luo,G.; Cianci,C.W.; Danetz,S.; Torri,A.; Tiley,L.; Krystal,M.; Yu,K.L.; Huang,S.; Gao,Q.; Meanwell,N.A.
参考来源:Bioorg Med Chem Lett 2001,11(17),2393