12459, Compound 12459
Chemical Name: 6,6'-(6-Amino-1,3,5-triazin-2,4-diyl)bis(imino)bis(1-methylquinolinium) dichloride
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma (Originator)
合成路线:By reaction of beta-alanine (I) with the phosphorous acid and PCl3 in chlorobenzene at 100 C.
合成路线:The condensation of 4,6-dichloro-1,3,5-triazin-2-amine (I) with 6-amino-1-methylquinolinium chloride (II) in refluxing ethanol/water gives the target bis quinolinium chloride.
📌 参考资料/链接：
参考文献标题:Arylamine derivs.and their use as anti-telomerase agent
文献作者:Mailliet,P.; Riou,J.-F.; Laoui,A.; Mergny,J.-L.; Lavelle,F.; Petitgenet,O.(Aventis Pharma SA)
参考来源:FR 2801588; WO 0140218