Clorsulon, L-631529, MK-401, Curatrem(Veterinary)
Chemical Name: 4-Amino-6-(trichlorovinyl)benzene-1,3-disulfonamide
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The reductive dechlorination of 3-(pentachloroethyl)nitrobenzene (I) with Fe in ethanol - water - HCl gives 3-(trichlorovinyl)aniline (II) [this compound is also obtained by dechlorination of 3-(pentachloroethyl)aniline (III) with Zn in refluxing ethanol].The reaction of (II) with chlorosulfonic acid at 130 C yields 4-amino-6-(trichlorovinyl)-1,3-benzenedisulfonyl chloride (IV),which is finally treated with liquid NH3 in methylene chloride
📌 参考资料/链接：
参考文献标题:Clorsulon
文献作者:Serradell,M.N.; Casta馿r,J.; Thorpe,P.J.
参考来源:Drugs Fut 1984,9(7),499
📄 详细内容
合成路线:The reductive dechlorination of 3-(pentachloroethyl)nitrobenzene (I) with Fe in ethanol - water - HCl gives 3-(trichlorovinyl)aniline (II) [this compound is also obtained by dechlorination of 3-(pentachloroethyl)aniline (III) with Zn in refluxing ethanol].The reaction of (II) with chlorosulfonic acid at 130 C yields 4-amino-6-(trichlorovinyl)-1,3-benzenedisulfonyl chloride (IV),which is finally treated with liquid NH3 in methylene chloride
参考文献标题:NVP-LBH589,a novel histone deacetylase inhibitor,activates caspase-3 and induces apoptosis of human tumor cells in vivo
文献作者:Lassota,P.T.; Sorensen,E.; Bao,R.; Atadja,P.; Perez,L.; Ross,B.; Rehemtulla,A.
参考来源:J Med Chem 1977,20(9),1255
合成路线:The reductive dechlorination of 3-(pentachloroethyl)nitrobenzene (I) with Fe in ethanol - water - HCl gives 3-(trichlorovinyl)aniline (II) [this compound is also obtained by dechlorination of 3-(pentachloroethyl)aniline (III) with Zn in refluxing ethanol].The reaction of (II) with chlorosulfonic acid at 130 C yields 4-amino-6-(trichlorovinyl)-1,3-benzenedisulfonyl chloride (IV),which is finally treated with liquid NH3 in methylene chloride
参考文献标题:
文献作者:Mrozik,H.H.(Merck & Co.,Inc.)
参考来源:BE 836626; DE 2556122; FR 2294710; GB 1485897; JP 7688937; JP 7783712; US 4064239