新产品编号:2034961

Chemical Name: N-[4(S)-Amino-5-(2-aminoethylamino)pentyl]-N'-nitroguanidine
项目整合开发状态: Biological Testing
项目研究机构: Northwestern University (Originator), University of Texas System (Originator)
合成路线:Boc-Nitroarginine (I) was activated as the mixed anhydride (II),which was further converted to the Weinreb amide (III) upon treatment with N,O-dimethylhydroxylamine.Reduction of (III) with LiAlH4 furnished N-Boc-nitroargininal (IV).This was reductively condensed with the mono-Boc-protected ethylenediamine (V) in the presence of sodium triacetoxyborohydride,yielding amine (VI).The Boc protecting groups of (VI) were finally removed by treatment with trifluoroacetic acid to provide the title compound.