新产品编号:2030215

Chemical Name: S-[2-[4-(1H-Indol-3-yl)butyryl]cyclopentyl]coenzyme A; 3'-O-Phosphonoadenosine-5'-diphosphoric acid 3(R)-hydroxy-3-[2-[2-[4-(1H-indol-3-yl)butyryl]cyclopentylsulfanyl]ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethylpropyl monoester
项目整合开发状态: Biological Testing
项目研究机构: Johns Hopkins University (Originator)
合成路线:3-Indolebutyric acid (I) was activated as the hydroxamate (II) by coupling with N,O-dimethylhydroxylamine in the presence of EDC and DMAP.Addition of cyclopentenylmagnesium bromide (III) to hydroxamate (II) furnished the unsaturated ketone (IV).Then,Michael addition of coenzyme A (V) to the unsaturated ketone (IV) in the presence of triethylammonium bicarbonate buffer provided the desired adduct.