新产品编号:2028633

Chemical Name: 3,4,5-Trimethoxybenzoic acid 2,4-diaminoquinazolin-6-ylmethyl ester
项目整合开发状态: Preclinical
项目研究机构: Melacure Therapeutics (Originator)
合成路线:Nitrile (II) was prepared by regioselective diazotization of triaminoquinazoline (I),followed by treatment with KCN and CuSO4.Conversion of nitrile (II) into aldehyde (III) was achieved by means of Ni-Al alloy in refluxing formic acid.Subsequent reduction of aldehyde (III) with NaBH4 gave alcohol (IV),which was further brominated to (V) using HBr in HOAc.Finally,displacement of the bromide of (V) with 3,4,5-trimethoxybenzoic acid (VI) provided the target trimethoxybenzoate ester.