TZDM

Chemical Name: N-[4-(6-[125I]Iodobenzothiazol-2-yl)phenyl]-N,N-dimethylamine
项目整合开发状态: Preclinical
项目研究机构: University of Pennsylvania (Originator)
合成路线:The cyclization of 4-bromo-2-sulfanylaniline (I) with 4-(dimethylamino)benzaldehyde (II) by heating at 180 C in DMSO gives 6-bromo-2-[4-(dimethylamino)phenyl]benzothiazole (III),which is treated with (Bu3Sn)2 (IV) and Pd(PPh3)4 and TEA in dioxane to yield the tributyltin derivative (V).Finally,this compound is treated with 125INa and H2O2 in ethanol/water to afford the target radiolabeled compound.