新产品编号:2027051

Chemical Name: 4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)isoxazol-3-yl]benzoic acid
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Bologna (Originator), Universit?degli Studi di Palermo (Originator), Universit?di Ferrara (Originator), University of Oklahoma Health Sci. Cent. (Originator)
合成路线:Wittig reaction of aldehyde (I) with methylene triphenylphosphorane produced olefin (II).Oxime (IV) was prepared from methyl 4-formylbenzoate (III) by treatment with hydroxylamine.The nitrile oxide generated from imine (IV) by chlorination,followed by elimination under basic conditions,underwent a [3+2] regioselective cycloaddition with alkene (II) to produce isoxazoline (V).Oxidation of the isoxazoline ring of (V) to the corresponding isoxazole derivative (VI) was accomplished by treatment with N-bromosuccinimide.Finally,ester hydrolysis with LiOH furnished the title carboxylic acid.