新产品编号:2006485
Chemical Name: N-Isopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-N-(pyridin-4-ylmethyl)acetamide
项目整合开发状态: Biological Testing
项目研究机构: Merck & Co. (Originator)
合成路线:Reductive amination of pyridine-4-carbaldehyde (I) with isopropylamine (II) in the presence of NaBH4 furnished the secondary amine (III).This was then acylated with the indoleacetic acid (IV) using PyBOP as the coupling reagent to yield the target amide.
📌 参考资料/链接：
参考文献标题:2-Arylindole-3-acetamides as FPP-competitive inhibitors of farnesyltransferase
文献作者:Lumma,W.C.; Quigley,A.G.; Sisko,J.T.; et al.
参考来源:221st ACS Natl Meet (April 1 2001,San Diego) 2001,Abst MEDI 154