新产品编号:1930549

Chemical Name: N,N-Diethyl-3-[3-(4-methoxybenzylidene)pyrrolidin-1-yl]propan-1-amine
项目整合开发状态: Preclinical
项目研究机构: Central Drug Research Institute (Originator)
合成路线:Condensation of 4-methoxybenzaldehyde (I) with gamma-butyrolactone (II) by means of NaOMe yields furanone derivative (III),which is then reduced in ether with LiAlH4 to afford diol (IV).Mesylation of (IV) by means of MsCl and Et3N in benzene provides dimesylate (V),which is finally condensed with amine (VI) with simultaneous cyclization in refluxing benzene.