A-316023

Chemical Name: N-Hydroxy-N-[4-[4-[4-(trifluoromethoxy)phenoxy]phenylsulfonylmethyl]tetrahydro-2H-pyran-4-yl]formamide
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:Alkylation of ketone (I) with sulfone (II) by means of BuLi yields derivative (III),which is then treated with POCl3 and pyridine to afford compound (IV).Reaction of (IV) with aqueous hydroxylamine (NH2OH) in THF provides derivative (V),which is finally treated with (VI) in THF to furnish the desired compound.