新产品编号:1927385
Chemical Name: 2-Chloro-8-(trifluoromethyl)pyrimido[4,5-b][1,5]benzothiazepin-5(6H)-one
项目整合开发状态: Biological Testing
项目研究机构: Signal (Originator)
合成路线:Reduction of nitrothiophenol (I) by hydrogenation over Pd/C in THF affords substituted aniline (II),which is then cyclized with 2,4-dichloropyrimidine-5-carbonyl chloride (III) in THF in the presence of Amberlyst A-27 to yield the final product.
📌 参考资料/链接：
参考文献标题:Synthesis and structure-activity relationship studies of conformationally restricted analogs of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3',5'-bis(trifluoromethyl)-phenyl)]carboxamide
文献作者:Suto,M.J.; Suto,C.; Goldman,M.E.; Palanki,M.S.S.; Erdman,P.E.
参考来源:Med Chem Res 2000,10(1),19