新产品编号:1921057

Chemical Name: 3-Methyl-2-oxo-N-[2-(2-phenyl-1H-indol-3-yl)ethyl]pentanamide
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Bromination of N-phthaloyl tryptamine (I) with pyridinium tribromide provided the 2-bromo indole (II).Suzuki coupling of bromide (II) with phenylboronic acid (III) gave the 2-phenyl indole (IV).The phthaloyl group of (IV) was then removed by treatment with dimethylamine to furnish 2-phenyltryptamine (V).Then condensation of amine (V) with 3-methyl-2-oxovaleric acid (VI) using EDC and HOBt yielded the corresponding amide.