新产品编号:1917893

Chemical Name: N-[cis-6-Hydroxy-1-(3-pyridinylmethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-2-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]acetamide
项目整合开发状态: Biological Testing
项目研究机构: R.W. Johnson (Originator)
合成路线:Aldol condensation of 3-pyridinecarboxaldehyde (II) with tetralone (I) in the presence of piperidine provided unsaturated ketone (III).This was subjected to reductive amination with ammonium formate and sodium cyanoborohydride to give the cis-aminotetralin (IV).Finally,amine (IV) was coupled with [4-(2-oxo-1-benzimidazolinyl)piperidin-1-yl]acetic acid (V) using HBTU.