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新产品编号:1914729

Chemical Name: 5,10,15,20-Tetrakis(3-fluoro-1-methylpyridinium-4-yl)porphyrin tetra(4-methylbenzenesulfonate)
项目整合开发状态: Preclinical
项目研究机构: Seoul National University (Originator), Seoul Women's University (Originator), Wonkwang University (Originator)
合成路线:Lithiation of 3-fluoropyridine (I) followed by formylation with methyl formate afforded aldehyde (II).Porphyrin (IV) was then prepared by condensation of aldehyde (II) with pyrrole (III) in refluxing propionic acid.Methylation of (IV) using methyl p-toluenesulfonate then gave the title pyridinium tosylate salt.
📌 参考资料/链接:
参考文献标题:Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors
文献作者:Lee,B.S.; Moon,S.C.; Shin,J.-H.; Jeong,B.H.; Kim,H.-S.; Yu,B.S.; Lee,J.-S.; Namgoong,S.K.
参考来源:Bioorg Med Chem Lett 2000,10(13),1435