新产品编号:1895745
Chemical Name: 4,4'-Bis(dimethylamino)-N,N'-(6,13-dioxo-6H,13H-diindolo[1,2-a:1',2'-d]pyrazine-2,9-diyl)bis(butanamide)
项目整合开发状态: Biological Testing
项目研究机构: Scripps Research Institute (Originator)
合成路线:Treatment of the indolecarboxylic acid (I) with EDC in the presence of DMAP gave rise to the dimeric diketopiperazine (II).Acid cleavage of the Boc protecting group of (II) afforded the free diamine (III),which was then coupled with 4-(dimethylamino)butyric acid (IV) using EDC and DMAP to furnish the title diamide.
📌 参考资料/链接:
参考文献标题:A new class of highly cytotoxic diketopiperazines
文献作者:Boger,D.L.; Fink,B.E.; Hedrick,M.P.
参考来源:Bioorg Med Chem Lett 2000,10(10),1019