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新产品编号:1892581

Chemical Name: 3,3,3',3'-Tetramethyl-1,1'-spirobiindane-6,6'-diol disulfate dipotassium salt
项目整合开发状态: Biological Testing
项目研究机构: Salk Institute for Biological Studies (Originator), University of California, San Diego (Originator)
合成路线:Condensation of phenol (I) with acetone (II) in refluxing HOAc/HCl affords diol (III),which is finally converted into the desired compound by first reaction with chlorosulfonic acid in pyridine followed by treatment with aqueous KOH.
📌 参考资料/链接:
参考文献标题:A new class of HIV-1 integrase inhibitors: The 3,3,3',3'-tetramethyl-1,1'-spirobi (indan)-5',5',6,6'-tetrol family
文献作者:Molteni,V.; Rhodes,D.; Rubins,K.; Hansen,M.; Bushman,F.D.; Siegel,J.S.
参考来源:J Med Chem 2000,43(10),2031