MRS-1743

Chemical Name: (1R,2R,3S,4R,5S)-1-(Hydroxymethyl)-4-[6-(3-iodobenzylamino)-9H-purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
项目整合开发状态: Preclinical
项目研究机构: National Cancer Institute (Originator), National Institutes of Health (Originator)
合成路线:The known methanocarba-adenosine (I) was alkylated with 3-iodobenzyl bromide (II) in hot DMF to give the intermediate ammonium salt (III),which was then subjected to Dimroth rearrangement with ammonium hydroxide to produce the title compound.