VUF-5574
Chemical Name: N-(2-Methoxyphenyl)-N'-[2-(3-pyridinyl)quinazolin-4-yl]urea
项目整合开发状态: Biological Testing
项目研究机构: Vrije Universiteit (Originator)
合成路线:The amide anion obtained from 2-aminobenzonitrile (I) and NaH in THF was added to 3-cyanopyridine (II) yielding 2-(3-pyridyl)-4-aminoquinazoline (III).This was then condensed with 2-methoxyphenyl isocyanate (IV) to furnish the title urea.
📌 参考资料/链接：
参考文献标题:Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor
文献作者:van Muijlwijk-Koezen,J.E.; Timmerman,H.; van der Goot,H.; Menge,W.M.P.B.; Frijtag von Drabbe K黱zel,J.; de Groote,M.; Ijzerman,A.P.
参考来源:J Med Chem 2000,43(11),2227