新产品编号:1887835

Chemical Name: 2'-Deoxy-5-fluoro-5'-[2-methyl-2-(2-nitrophenyl)propionyl]uridine
项目整合开发状态: Biological Testing
项目研究机构: State University of New Jersey (Originator)
合成路线:Esterification of 2-nitrophenylacetic acid (I) with SOCl2 in MeOH produced methyl ester (II).Subsequent dialkylation of (II) using methyl iodide and NaH in the presence of 18-crown-6 gave methyl 2-nitrophenyl-2-methylpropionate (III),which was hydrolyzed to carboxylic acid (IV) with NaOH in MeOH.Finally,chemoselective acylation of the primery hydroxy group of 5-fluoro-2'-deoxyuridine (V) with (IV) under Mitsunobu conditions yielded the title ester.