新产品编号:1884671

Chemical Name: N-[1-Benzyl-5-oxopyrrolidin-2(S)-ylcarbonyl]-4-(2,6-dichlorobenzamido)-L-phenylalanine
项目整合开发状态: Preclinical
项目研究机构: Roche (Originator)
合成路线:Coupling of N-benzylpyroglutamic acid (I) with 4-nitrophenylalanine methyl ester (II) by means of O-benzotriazolyl-N,N,N?N?tetramethyluronium hexafluorophosphate (HBTU) produced amide (III).After stannous chloride mediated reduction of the nitro group of (III),the resulting aniline (IV) was coupled with 2,6-dichlorobenzoic acid (V) to give diamide (VI).The title carboxylic acid was then obtained by ester hydrolysis with NaOH.