新产品编号:1881507

Chemical Name: 4-Chloro-2,6-bis(methylsulfanyl)pyrimidine-5-carbonitrile
项目整合开发状态: Biological Testing
项目研究机构: Central Drug Research Institute (Originator)
合成路线:The condensation of ethyl 2-cyano-3,3-dimethylthioacrylate (I) with S-methylisothiourea (II) in refluxing ethanol yielded pyrimidinone (V).Alternatively,the intermediate pyrimidinone (V) was obtained by condensation of 2-cyano-3,3-dimethylthioacrylamide (III) with anhydride (IV).Subsequent chlorination of (V) with refluxing phosphoryl chloride provided the title chloropyrimidine.