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新产品编号:1876761

Chemical Name: N,N'-Bis[(1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13b,14,14a-dodecahydrobenz[g]indolo[2,3-a]quinolizin-1-ylcarbonyl]hexane-1,6-diamine dihydrochloride
项目整合开发状态: Biological Testing
项目研究机构: University of Mississippi (Originator), University of Tennessee, Memphis (Originator)
合成路线:The title yohimbine dimer was prepared by coupling yohimbinic acid (I) with 1,6-hexanediamine (II) in the presence of dicyclohexylcarbodiimide and hydroxybenzotriazole,followed by conversion to the dihydrochloride salt.
📌 参考资料/链接:
参考文献标题:Yohimbine dimers exhibiting binding selectivities for human alpha2a - versus alpha2b adrenergic receptors
文献作者:Zheng,W.; Lei,L.; Lalchandani,S.; Sun,G.; Feller,D.R.; Miller,D.D.
参考来源:Bioorg Med Chem Lett 2000,10(7),627