新产品编号:1873597

Chemical Name: 5-[2-[4-(3-Chlorophenyl)piperazin-1-yl]ethylamino]-3-methyl-4-benzyl-6H-1,2-oxazin-6-one
项目整合开发状态: Preclinical
项目研究机构: Universit?d'Auvergne-Clermont-Ferrand (Originator)
合成路线:Oxazinone (II) was prepared by cyclization of the unsaturated keto acid (I) with hydroxylamine.Subsequent radical bromination of (II) with N-bromosuccinimide (NBS) provided the alpha-bromobenzyl derivative (III).Alkylation of 3-chlorophenyl piperazine (IV) with N-(2-bromoethyl)phthalimide (V) gave adduct (VI).Further hydrazinolysis of the phthaloyl group of (VI) yielded the primary amine (VII).Finally,condensation between bromide (III) and amine (VII) in refluxing THF furnished the title 5-amino oxazinone derivative.