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新产品编号:1870433

Chemical Name: (2S,3S)-Bis[3-(3,4-Diacetoxyphenyl)-2(E)-propenoyloxy]butanedioic acid
项目整合开发状态: Preclinical
项目研究机构: US Department of Health & Human Services (Originator)
合成路线:Reaction of di-tert-butyl D-tartrate (I) with 3,4-diacetylcaffeoyl chloride (II) in the presence of pyridine gave the chicoric acid derivative (III).The tert-butyl ester groups were then cleaved by treatment with trifluoroacetic acid in CH2Cl2.
📌 参考资料/链接:
参考文献标题:Acetylated and related analogues of chicoric acid as HIV integrase inhibitors
文献作者:Zhaiwei,L.; Zhao,H.; Neamati,N.; Burke,T.R.; Pommier,Y.(US Department of Health & Human Services)
参考来源:WO 0063152