beta-L-IV-OddU

Chemical Name: 5-[(E)-2-Iodovinyl)-1-[2(S)-(hydroxymethyl)-1,3-dioxolan-4(S)-yl]pyrimidine-2,4(1H,3H)-dione; 5-[(E)-2-Iodovinyl]-1-[2(S)-(hydroxymethyl)-1,3-dioxolan-4(S)-yl]uracil
项目整合开发状态: Biological Testing
项目研究机构: University of Georgia (Originator), Yale University (Originator)
合成路线:The condensation of the chiral dioxolane (I) with 5(E)-(2-bromovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II),which is purified by chromatography.Finally,this compound is deprotected by means of TBAF in acetonitrile.(1,2)

合成路线:The condensation of the chiral dioxolane (I) with 5(E)-(2-chlorovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II) that is purified by chromatography.Finally,this compound is deprotected by means of TBAF in acetonitrile.

合成路线:The condensation of the chiral dioxolane (I) with 5(E)-(2-iodovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II),which is purified by chromatography.Finally,this compound is deprotected by means of TBAF in acetonitrile.