Acyclic retinoid, Polyprenoic acid, NK-333, NIK-333, E-5166
3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸Chemical Name: (2E,4E,6E,10E)-3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid; 4,5-Didehydrogeranylgeranoic acid
CAS No. 81485-25-8, 80370-67-8 (no stereochemistry)
项目整合开发状态: Phase II
项目研究机构: Eisai (Originator), Nikken Chemicals (Not Determined)
合成路线:The Wittig condensation of 6,10,14-trimethylpentadeca-3,5,9,13-tetraen-2-one (I) with triethyl phosphonoacetate (II) by means of NaH in refluxing hexane gives ethyl 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoate (III),which is then hydrolyzed with KOH in hot isopropanol.
📌 参考资料/链接：
参考文献标题:3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
文献作者:Yamatsu,I.; Tagaya,O.; Abe,S.; Abe,K.; Suzuki,K.; Yamada,K.; Suzuki,T.; Inai,Y.; Suzuki,Y.(Eisai Co.,Ltd.)
参考来源:BE 888290; US 4917829
📄 详细内容
合成路线:The Wittig condensation of 6,10,14-trimethylpentadeca-3,5,9,13-tetraen-2-one (I) with triethyl phosphonoacetate (II) by means of NaH in refluxing hexane gives ethyl 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoate (III),which is then hydrolyzed with KOH in hot isopropanol.
参考文献标题:Method for treatment of inflammation
文献作者:Katoh,Y.; et al.(Eisai Co.,Ltd.)
参考来源:EP 0107188; JP 59073516
合成路线:The Wittig condensation of 6,10,14-trimethylpentadeca-3,5,9,13-tetraen-2-one (I) with triethyl phosphonoacetate (II) by means of NaH in refluxing hexane gives ethyl 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoate (III),which is then hydrolyzed with KOH in hot isopropanol.
参考文献标题:E-5166
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(7),562
产品链接: CAS No. 81485-25-8››