JANEX-3, WHI-P180

3-(6,7-二甲氧基喕那唑-4-乙氨基)苯.尾.Chemical Name: 3-(6,7-Dimethoxyquinazolin-4-ylamino)phenol
CAS No. 153437-55-9
项目整合开发状态: Preclinical
项目研究机构: AstraZeneca (Originator), Parker Hughes Institute (Originator)
合成路线:The cyclization of 4,5-dimethoxyanthranilic acid (I) with formamide by heating at 190 C gives 6,7-dimethoxyquinazoline (II),which is treated with refluxing SOCl2 to yield 4-chloro-6,7-dimethoxyquinazoline (III).Finally,this compound is condensed with 3-aminophenol (IV) in refluxing THF.