合成路线:The reaction of 2-fluoro-4-chloro-5-sulfamoylbenzoic acid (I) with refluxing SOCl2 gives the corresponding acyl chloride (II),which by reaction with aqueous NH3 is transformed into the amide (III).The dehydration of (III) with refluxing POCl3 affords the nitrile (IV),which is then condensed with thenylamine (V) to yield 4-chloro-2-thenylamino-5-sulfamoylbenzonitrile (VI).Finally,this compound is cyclized with sodium azide in DMF at 100 C.
参考文献标题:5-Phenyltetrazole derivatives
文献作者:Popelak,A.; et al.(Boehringer Ingelheim GmbH)
参考来源:DE 1815922; FR 2026688; GB 1237790; US 3665002
合成路线:The reaction of 2-fluoro-4-chloro-5-sulfamoylbenzoic acid (I) with refluxing SOCl2 gives the corresponding acyl chloride (II),which by reaction with aqueous NH3 is transformed into the amide (III).The dehydration of (III) with refluxing POCl3 affords the nitrile (IV),which is then condensed with thenylamine (V) to yield 4-chloro-2-thenylamino-5-sulfamoylbenzonitrile (VI).Finally,this compound is cyclized with sodium azide in DMF at 100 C.
参考文献标题:Azosemide
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.; Hillier,K.
参考来源:Drugs Fut 1979,4(6),393
产品链接: CAS No. 27589-33-9››