D-22558

2-[1-(4-氟苯基)吲哚-3-基]-N-(4-吡啶基)乙酰胺Chemical Name: 2-[1-(4-Fluorobenzyl)indol-3-yl]-N-(4-pyridyl)acetamide
CAS No. 176204-36-7
项目整合开发状态: Preclinical
项目研究机构: Asta Medica (Originator)
合成路线:Indolylacetic acid (I) was esterified with ethanolic HCl,and the resulting ethyl ester (II) was alkylated with 4-fluorobenzyl chloride (III) in the presence of NaH to afford the N-fluorobenzyl indole (IV).Subsequent saponification of (IV) provided carboxylic acid (V).This was finally coupled with 4-aminopyridine (VI) by means of activation with 2-chloro-1-methylpyridinium iodide.