NSC-697726, RH1
2,5-二(1-氮丙啶基)-3-(羟甲基)-6-甲基-2,5-环己二烯-1,4-二酮Chemical Name: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
CAS No. 221635-42-3
项目整合开发状态: Phase I/II
项目研究机构: Cancer Research UK (Originator), National Cancer Institute (Originator)
合成路线:2-(Hydroxymethyl)-5-methyl-1,4-benzoquinone (III) was obtained by hydroxymethylation of toluhydroquinone (I) with formaldehyde,followed by oxidation of the resulting hydroquinone (II) with Ag2O.Then,addition of aziridine (IV) to quinone (III) furnished the title compound.
📌 参考资料/链接：
参考文献标题:A new screening system for NAD(P)H: quinone oxidoreductase (NQO1)-directed antitumor quinones: Identification of a new aziridinylbenzoquinone,RH1,as a NQO1-directed antitumor agent
文献作者:Winski,S.L.; Hargreaves,R.H.J.; Butler,J.; Ross,D.
参考来源:Clin Cancer Res 1998,4(12),3083
📄 详细内容
合成路线:2-(Hydroxymethyl)-5-methyl-1,4-benzoquinone (III) was obtained by hydroxymethylation of toluhydroquinone (I) with formaldehyde,followed by oxidation of the resulting hydroquinone (II) with Ag2O.Then,addition of aziridine (IV) to quinone (III) furnished the title compound.
参考文献标题:Synthesis and antitumor and antibacterial activity of benzoquinones related to the mitomycins
文献作者:Witty,T.R.; Remers,W.A.
参考来源:J Med Chem 1973,16(11),1280
产品链接: CAS No. 221635-42-3››