合成路线:Addition of dodecylmagnesium bromide to 5-triethylsilyl-3-furaldehyde (I) followed by in situ acetylation using acetic anhydride gives 4-(1-acetoxytridecyl)-2-triethylsilylfuran (II).Singlet oxygen oxidation of (II) in THF,in the presence of water,gives AGN-190383.
参考文献标题:A novel synthesis of 2,4-substituted furans
文献作者:Lee,G.C.M.; Holmes,J.M.; Garst,M.E.
参考来源:198th ACS Natl Meet (Sept 10-15,Miami Beach) 1989,Abst ORGN 194
合成路线:Addition of dodecylmagnesium bromide to 5-triethylsilyl-3-furaldehyde (I) followed by in situ acetylation using acetic anhydride gives 4-(1-acetoxytridecyl)-2-triethylsilylfuran (II).Singlet oxygen oxidation of (II) in THF,in the presence of water,gives AGN-190383.
参考文献标题:AGN-190383
文献作者:Lee,G.; De Vries,G.; Harcourt,D.; Holmes,J.; Amdahl,L.; Syage,E.; Wenzel,M.; Wheeler,L.; Garst,M.
参考来源:Drugs Fut 1990,15(6),561
合成路线:Addition of dodecylmagnesium bromide to 5-triethylsilyl-3-furaldehyde (I) followed by in situ acetylation using acetic anhydride gives 4-(1-acetoxytridecyl)-2-triethylsilylfuran (II).Singlet oxygen oxidation of (II) in THF,in the presence of water,gives AGN-190383.
参考文献标题:Process for preparing 5-substituted-3,-furaldehyde
文献作者:Lee,G.C.M.(Allergan,Inc.)
参考来源:EP Appl.89310601; US 259225
产品链接: CAS No. 120755-15-9››