GU-285
2-(4-氨基-1-苯基-1H-吡唑并[3,4-d]嘧啶-6-基硫烷基)丙酰胺Chemical Name: 2-(4-Amino-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylsulfanyl)propionamide
CAS No. 134896-40-5
项目整合开发状态: Preclinical
项目研究机构: Griffith University (Originator), University of Queensland (Originator)
合成路线:Monoalkylation of 1-phenylpyrazolo[3,4-d]pyrimidine-4,6-dithione (I) with 2-bromopropionamide (II) produced selectively the 6-substituted compound (III).Subsequent methylation of the free 4-mercapto group yielded the 4-methylsulfanyl derivative (IV).Finally,displacement of the methylsulfanyl group of (IV) with ethanolic ammonia in a sealed tube at 100 C furnished the title amino compound.
📌 参考资料/链接：
参考文献标题:1-Phenylpyrazolo[3,4-d]pyrimidines; structure-activity relationships for C6 substituents at A1 and A2A adenosine receptors
文献作者:Chebib,M.; McKeveney,D.; Quinn,R.J.
参考来源:Bioorg Med Chem 2000,8(11),2581
📄 详细内容
合成路线:Monoalkylation of 1-phenylpyrazolo[3,4-d]pyrimidine-4,6-dithione (I) with 2-bromopropionamide (II) produced selectively the 6-substituted compound (III).Subsequent methylation of the free 4-mercapto group yielded the 4-methylsulfanyl derivative (IV).Finally,displacement of the methylsulfanyl group of (IV) with ethanolic ammonia in a sealed tube at 100 C furnished the title amino compound.
参考文献标题:Mono-alpha-carbamoylethylthio-substituted pyrazolo[3,4-d]pyrimidines: The position of substitution
文献作者:Quinn,R.J.; et al.
参考来源:Aust J Chem 1991,44(5),753
产品链接: CAS No. 134896-40-5››