V-102862, CO-102862
2-(4-(4-氟苯氧基)亚苄基)肼甲酰胺Chemical Name: 4-(4-Fluorophenoxy)benzaldehyde semicarbazone
CAS No. 181144-66-1
项目整合开发状态: Preclinical
项目研究机构: University of Saskatchewan (Originator), CoCensys (Licensee)
合成路线:Condensation of 4-fluorophenol (I) with 4-fluorobenzaldehyde (II) by heating with K2CO3 in N,N-dimethylacetamide provides 4-(4-fluorophenoxy)benzaldehyde (III),which is finally converted into the target product by reaction with semicarbazide hydrochloride (IV) and NaOAc in the refluxing mixture EtOH/H2O.
📌 参考资料/链接：
参考文献标题:Semicarbazones having CNS activity and pharmaceutical preparations containing same
文献作者:Dimmock,J.R.; Puthucode,R.N.(University of Saskatchewan)
参考来源:EP 0836591; JP 1999506109; US 5741818; WO 9640628
📄 详细内容
合成路线:Condensation of 4-fluorophenol (I) with 4-fluorobenzaldehyde (II) by heating with K2CO3 in N,N-dimethylacetamide provides 4-(4-fluorophenoxy)benzaldehyde (III),which is finally converted into the target product by reaction with semicarbazide hydrochloride (IV) and NaOAc in the refluxing mixture EtOH/H2O.
参考文献标题:Development of a high-performance liquid chromatographic-tandem mass spectrometric method for the determination of pharmacokinetics of Co 102862 in mouse,rat,monkey and dog plasma
文献作者:Ramu,K.; Lam,G.N.; Chien,B.
参考来源:J Chromatogr B - Biomed Appl 2000,749(1),1
合成路线:Condensation of 4-fluorophenol (I) with 4-fluorobenzaldehyde (II) by heating with K2CO3 in N,N-dimethylacetamide provides 4-(4-fluorophenoxy)benzaldehyde (III),which is finally converted into the target product by reaction with semicarbazide hydrochloride (IV) and NaOAc in the refluxing mixture EtOH/H2O.
参考文献标题:Anticonvulsant activity of various aryl,aryldine and aryloxyaryl semicarbazones
文献作者:Quail,J.W.; Dimmock,J.R.; Puthucode,R.N.; Pugazhenthi,U.; Stables,J.P.
参考来源:Eur J Med Chem 1998,33(7-8),595
产品链接: CAS No. 181144-66-1››