Wy-47766

2-(3-甲氧基苄磺基)-3H-吡唑[4,5-c]吡啶Chemical Name: 2-(3-Methoxybenzylsulfinyl)-3H-imidazo[4,5-c]pyridine
CAS No. 134217-27-9
项目整合开发状态: Phase II
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:Reaction of 3,4-diaminopyridine (I) with potassium O-ethyl dithiocarbonate produced 2-mercaptoimidazo[4,5-c]pyridine (II),which was susequently alkylated with 3-methoxybenzyl bromide (III) and KOH,yielding sulfide (IV).Selective oxidation of (IV) to the target sulfoxide was then achieved by treatment with N-chlorosuccinimide in the presence of NaHCO3 at 0 C.