PFS-1144, EO-122
1-氮双环[2.2.2]辛烷-3-羧酰胺,N-(2,6-二甲基苯基)-,盐酸盐(1:1)Chemical Name: N-(2,6-Dimethylphenyl)quinuclidine-3-amine hydrochloride
CAS No. 23581-62-6
项目整合开发状态: Preclinical
项目研究机构: Purdue Pharma (Originator)
合成路线:The synthesis of EO 122 starts from quinuclidine-3-carboxylic acid (I),which is converted to the acid chloride (II) by oxalyl chloride.The addition of 2,6-dimethylaniline (III) to the acid chloride yields EO-122.
📌 参考资料/链接：
参考文献标题:EO-122
文献作者:Oppenheimer,E.; Binah,O.
参考来源:Drugs Fut 1988,13(8),724
📄 详细内容
合成路线:The synthesis of EO 122 starts from quinuclidine-3-carboxylic acid (I),which is converted to the acid chloride (II) by oxalyl chloride.The addition of 2,6-dimethylaniline (III) to the acid chloride yields EO-122.
参考文献标题:A preclinical study of EO-122,a new lidocaine-lik
文献作者:Oppenheimer,E.; Kaplinsky,E.; Kariv,E.; Bruckstein,R.; Cohen,S.
参考来源:Angiology 1980,31410
合成路线:The synthesis of EO 122 starts from quinuclidine-3-carboxylic acid (I),which is converted to the acid chloride (II) by oxalyl chloride.The addition of 2,6-dimethylaniline (III) to the acid chloride yields EO-122.
参考文献标题:Studie in the quinudidine line.3-Quinudialine-car
文献作者:Renk,E.; Grob,C.A.
参考来源:Helv Chim Acta 1954,371689
产品链接: CAS No. 23581-62-6››