L-731988
1H-吡咯-2-丁酸,1-[(4-氟苯基)甲基]-a,g-二氧合醇-Chemical Name: 4-[1-(4-Fluorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxobutyric acid
CAS No. 251922-77-7
项目整合开发状态: Preclinical
项目研究机构: Amgen (Originator), Merck & Co. (Originator)
合成路线:The alkylation of 2-acetylpyrrole (I) with 4-fluorobenzyl bromide (II) in the presence of NaH provided the N-benzyl indole (III).Subsequent Claisen condensation of (III) with dimethyl oxalate furnished diketo ester (IV),which was finally hydrolyzed with NaOH to the title carboxylic acid.
📌 参考资料/链接：
参考文献标题:HIV integrase inhibitors
文献作者:Selnick,H.G.; Hazuda,D.J.; Egbertson,M.; Guare,J.P.Jr.; Clark,D.L.; Wai,J.S.; Young,S.D.; Medina,J.C.(Merck & Co.,Inc.; Tularik Inc.)
参考来源:WO 9962513