BY-1947
11-乙基-3-甲氧基二苯并[b,f][1,4]氧西平-8-羧酸Chemical Name: 11-Ethyl-3-methoxydibenzo[b,f][1,4]oxazepine-8-carboxylic acid
CAS No. 81237-48-1
项目整合开发状态: Preclinical
项目研究机构: Chugai (Originator)
合成路线:The cyclization of ethyl 3-propionylamino-4-(3-methoxyphenoxy)benzoate (I) by means ot POCl3 in refluxing toluene gives ethyl 11-ethyl-3-methoxydibenz[b,f][1,4]oxazepine-8-carboxylate (II),which is then hydrolyzed with NaOH in refluxing methanol water.
📌 参考资料/链接：
参考文献标题:Dibenzoxazepine derivative,and pharmaceutical composition comprising the same
文献作者:Sasahara,K.; Muramaki,Y.; Neichi,T.; Koizumi,M.; Matsushita,H.; Hata,S.; Honda,M.; Nakakimura,H.; Noda,Y.(Chugai Pharmaceutical Co.Ltd.)
参考来源:EP 0040860; JP 1981166180; US 4435391
📄 详细内容
合成路线:The cyclization of ethyl 3-propionylamino-4-(3-methoxyphenoxy)benzoate (I) by means ot POCl3 in refluxing toluene gives ethyl 11-ethyl-3-methoxydibenz[b,f][1,4]oxazepine-8-carboxylate (II),which is then hydrolyzed with NaOH in refluxing methanol water.
参考文献标题:BY-1947
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1984,9(3),173
产品链接: CAS No. 81237-48-1››