XE-991
10,10-双(4-萘甲基)-9(10H)-蒽酮Chemical Name: 10,10-Bis(4-pyridylmethyl)anthracen-10(9H)-one
CAS No. 122955-42-4
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The title compound was prepared by alkylation of anthrone (I) with 4-picolyl chloride (II) in the presence of an alkaline hydroxide and a phase-transfer catalyst.
📌 参考资料/链接：
参考文献标题:alpha,alpha-Disubstd.aromatics and heteroaromatics as cognition enhancers
文献作者:Earl,R.A.; Myers,M.J.; Nickolson,V.J.(DuPont Pharmaceuticals Co.)
参考来源:EP 0311010; US 5173489
📄 详细内容
合成路线:The title compound was prepared by alkylation of anthrone (I) with 4-picolyl chloride (II) in the presence of an alkaline hydroxide and a phase-transfer catalyst.
参考文献标题:Acetylcholine release enhancers related to linopirdine: A structure-activity relationship study.II
文献作者:Drummond,S.; Wilkerson,W.W.; Calabrese,J.C.; Earl,R.A.; Teleha,C.A.; Zaczek,R.; Voss,M.E.
参考来源:Eur J Med Chem 1996,31(4),319
产品链接: CAS No. 122955-42-4››