SB-265610

1-(2-溴苯基)-3-(4-氰基-1H-苯并三唑-7-基)脲Chemical Name: N-(2-Bromophenyl)-N'-(4-cyano-1H-1,2,3-benzotriazol-7-yl)urea
CAS No. 211096-49-0
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Reaction of 2-bromo-5-nitroaniline (I) with cuprous cyanide in the presence of pyridine in hot DMF afforded the 2-aminobenzonitrile (II).This was converted to the phenylenediamine derivative (III) upon treatment with tetramethylhydrazine iodide in the presence of sodium tert-pentoxide.The target benzotriazole system (IV) was then produced by diazotization of diamine (III) with NaNO2 in hot HOAc.Subsequent nitro group reduction by catalytic hydrogenation yielded 7-amino-4-cyanobenzotriazole (V).The aminobenzotriazole (V) was finally converted to the desired urea by condensation with 2-bromophenyl isocyanate (VI) in hot DMF.