新产品编号:816821

1-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-4-(羟基亚氨基)-3,4-二氢嘧啶-2(1H)-酮 (莫钠皮拉韦杂质)Chemical Name: N6-Hydroxycytidine
CAS No. 3258-02-4, 85373-26-8 (deleted CAS)
项目整合开发状态: Preclinical
项目研究机构: Pharmasset (Originator)
合成路线:Treatment of 2',3'-O-isopropylidene-5'-O-trityluridine (I) with 2,4,6-triisopropylbenzenesulfonyl chloride (II) in the presence of DMAP affords the sulfonic ester derivative (III).Subsequent displacement of sulfonate (III) with hydroxylamine leads to the protected N-hydroxycytidine (IV).The protecting groups of (IV) are finally removed with aqueous trifluoroacetic acid to furnish the title compound.