LF-1695

[5-氨基-2-(4-甲基哌啶-1-基)苯基]-(4-氯苯基)甲酮Chemical Name: 1-[2-(4-Methylpiperidin-1-yl)-5-aminophenyl]-1-(4-chlorophenyl)methanone; 2-(4-Methylpiperidin-1-yl)-5-amino-4'-chlorobenzophenone
CAS No. 86187-86-2
项目整合开发状态: Discontinued
项目研究机构: Fournier (Originator)
合成路线:A more complete synthesis for LF-1695 has been reported:The reaction of 2-chloro-5-nitrobenzoic acid (I) with PCl5 in hot chlorobenzene gives the corresponding acyl chloride (II),which is condensed with chlorobenzene (III) by means of AlCl3,yielding 2,4'-dichloro-5-nitrobenzophenone (IV).The condensation of (IV) with 4-methylpiperidine (V) by means of K2CO3 at 150 C affords 4'-chloro-2-(4-methylpiperidin-1-yl)-5-nitrobenzophenone (VI),which is finally reduced with Fe or SnCl2 and HCl.