Lonazolac calcium, Lonax, Floxan, Irritren
[3-(4-氯苯基)-1-苯基-1H-吡唑-4-基]乙酸Chemical Name: 3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid calcium salt
CAS No. 53808-88-1 (free acid)
项目整合开发状态: Launched-1981
项目研究机构: Altana Pharma (Originator)
合成路线:The pyrazole-4-carbaldehyde (I) synthesized according to Vilsmeier is reduced to the alcohol (II),which is chlorinated to (III).(III) is reacted with sodium cyanide to give the nitrile (IV),which is hydrolyzed to lonazolac (V).The calcium salt,slightly soluble in water,is formed by adding calcium chloride to (V).
📌 参考资料/链接：
参考文献标题:Lonazolac calcium
文献作者:Underhalt,B.
参考来源:Drugs Fut 1982,7(2),110
📄 详细内容
合成路线:The pyrazole-4-carbaldehyde (I) synthesized according to Vilsmeier is reduced to the alcohol (II),which is chlorinated to (III).(III) is reacted with sodium cyanide to give the nitrile (IV),which is hydrolyzed to lonazolac (V).The calcium salt,slightly soluble in water,is formed by adding calcium chloride to (V).
参考文献标题:Synthese und physikalisch-chemische Eigenschaften von Lonazolac-Ca,einem neuen Antiphlogistikum / Antirheumatikum
文献作者:Rainer,G.; Kr黦er,U.; Klemm,K.
参考来源:Arzneim-Forsch Drug Res 1981,31(4),649
产品链接: CAS No. 53808-88-1››