Trimelamol, CB-10375
[1,3,5-三嗪-2,4,6-三基三(甲基亚胺)]三甲醇Chemical Name: N(2),N(4),N(6)-Trihydroxymethyl-N(2),N(4),N(6)-trimethylmelamine
CAS No. 64124-21-6
项目整合开发状态: Phase II
项目研究机构: Institute of Cancer Research (Originator)
合成路线:The cyclization of cyanogen chloride (I) with aqueus methylamine (II) at 150 C in a pressure vessel gives N2,N4,N6-trimethylmelamine (III),which is then treated with aqueous formaldehyde at pH 8.9.
📌 参考资料/链接：
参考文献标题:Trimelamol
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(4),291
📄 详细内容
合成路线:The cyclization of cyanogen chloride (I) with aqueus methylamine (II) at 150 C in a pressure vessel gives N2,N4,N6-trimethylmelamine (III),which is then treated with aqueous formaldehyde at pH 8.9.
合成路线:Treatment of alcohol (I) with methanesulfonyl chloride in the presence of triethylamine provided mesylate (II),which was condensed with the spirosubstituted piperidine (III) to give the desired compound.
参考文献标题:Spiro-substituted piperidines as neurokinin receptor antagonists.III.Synthesis of (?-N-[2-(3,4-dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and evaluation of NK1-NK2 dual antagonistic activities
文献作者:Kubota,H.; Kakefuda,A.; Okamoto,Y.; Fujii,M.; Yamamoto,O.; Yamagiwa,Y.; Orita,M.; Ikeda,K.; Takeuchi,M.; Shibanuma,T.; Isomura,Y.
参考来源:Chem Pharm Bull 1998,46(10),1538
产品链接: CAS No. 64124-21-6››