EMATE
[(8R,9S,13S,14S)-13-甲基-17-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊二烯并[a]菲-3-基]氨基磺酸Chemical Name: 3-(Sulfamoyloxy)estra-1,3,5(10)-trien-17-one; Estrone-3-O-sulfamate
CAS No. 148672-09-7
项目整合开发状态: Preclinical
项目研究机构:
合成路线:By esterification of 5,6,7,8-tetrahydronaphthalen-2-ol (I) with chlorosulfonamide (II) and NaH in DMF.
合成路线:By esterification of estrone (I) with chlosulfonamide (II) and NaH in DMF.
📌 参考资料/链接：
参考文献标题:Phosphonates and thiophosphonates as sulfate surrogates: Synthesis of estrone 3-methylthiophosphonate a potent inhibitor of estrone sulfatase
文献作者:Reed,M.J.; Potter,B.V.L.; Purohit,A.; Howarth,N.M.; Cooper,G.; Duncan,L.J.
参考来源:Bioorg Med Chem Lett 1993,3(2),313-318
📄 详细内容
合成路线:By esterification of 5,6,7,8-tetrahydronaphthalen-2-ol (I) with chlorosulfonamide (II) and NaH in DMF.
合成路线:By esterification of estrone (I) with chlosulfonamide (II) and NaH in DMF.
参考文献标题:Steroid sulphatase inhibitors: a new endocrine therapy
文献作者:Potter,B.V.L.; Howarth,N.M.; Purohit,A.; Reed,M.J.
参考来源:Drugs Fut 1994,19(7),673
产品链接: CAS No. 148672-09-7››