trans-2-EN-valproic acid

(E)-2-丙基戊-2-烯酸Chemical Name: 2-Propyl-2(E)-pentenoic acid
CAS No. 33786-47-9
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:Dehydrobromination of the ethyl ester of 2-bromo-2-propylpentanoic acid (I) by means of a tertiary amine yields a mixture of the isomers of 2-propyl-2-pentenoic acid ethyl ester (IIa) and (IIb),from which the major component,the trans-isomer (IIa),is separated and saponified to obtain trans-2-propyl-2-pentenoic acid (trans-2-en-valproic acid) (H.Schafer,personal communication).