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项目整合精选>>>Mepirodipine hydrochloride, Barnidipine hydrochloride, EU-730, YM-730, YM-09730-5, Cyress, Vasexten, Hypoca
Mepirodipine hydrochloride, Barnidipine hydrochloride, EU-730, YM-730, YM-09730-5, Cyress, Vasexten, Hypoca
(4S)-2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二羧酸 (3S)-1-苄基-3-吡咯烷基-甲基酯Chemical Name: 2,6-Dimethyl-4(S)-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[1-benzylpyrrolidin-3(S)-yl] 5-methyl diester hydrochloride
CAS No. 104713-75-9 (free base), 71863-55-3 (undefined stereoch.)
项目整合开发状态: Launched-1992
项目研究机构: Yamanouchi (Originator)
合成路线:By cyclocondensation of 3-nitrobenzaldehyde (I) with methyl 3-aminocrotonate (II) and 1-benzyl-3-(acetoacetoxy)pyrrolidine (III) in refluxing isopropanol.The pyrrolidine (III) is obtained as follows:The condensation of 2-hydroxysuccinic acid (IV) with benzylamine (VI),which is reduced with LiAlH4 in dry THF yielding N-benzyl-3-hydroxypyrrolidine (VIII).Finally,this compound is condensed with diketene (VII) by means of sodium acetate at 80 C.
📌 参考资料/链接：
参考文献标题:1,4-Dihydropyridine-3,5-dicarboxylic acid ester de
文献作者:Kojima,T.; Takenaka,T.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:DE 2904552; US 4220649
📄 详细内容
合成路线:By cyclocondensation of 3-nitrobenzaldehyde (I) with methyl 3-aminocrotonate (II) and 1-benzyl-3-(acetoacetoxy)pyrrolidine (III) in refluxing isopropanol.The pyrrolidine (III) is obtained as follows:The condensation of 2-hydroxysuccinic acid (IV) with benzylamine (VI),which is reduced with LiAlH4 in dry THF yielding N-benzyl-3-hydroxypyrrolidine (VIII).Finally,this compound is condensed with diketene (VII) by means of sodium acetate at 80 C.
参考文献标题:YM-09730-5
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(7),634
合成路线:By cyclocondensation of 3-nitrobenzaldehyde (I) with methyl 3-aminocrotonate (II) and 1-benzyl-3-(acetoacetoxy)pyrrolidine (III) in refluxing isopropanol.The pyrrolidine (III) is obtained as follows:The condensation of 2-hydroxysuccinic acid (IV) with benzylamine (VI),which is reduced with LiAlH4 in dry THF yielding N-benzyl-3-hydroxypyrrolidine (VIII).Finally,this compound is condensed with diketene (VII) by means of sodium acetate at 80 C.
参考文献标题:Synthesis of 14C-and 2H-labeled (3S)-1-benzyl-3-py
文献作者:Tamazawa,K.; Takeuchi,M.; Arima,H.
参考来源:J Label Compd Radiopharm 1988,25(2),161
产品链接: CAS No. 104713-75-9›› 产品链接: CAS No.71863-55-3››