Biofor-389, BF-389

(4E)-4-[(3,5-二叔丁基-4-羟基苯基)亚甲基]-2-甲基恶嗪烷-3-酮Chemical Name: 4-(3,5-Di-tert-butyl-4-hydroxybenzylidene)-2-methyl-3,4,5,6-tetrahydro-2H-1,2-oxazin-3-one; 4-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-methyl-5,6-dihydro-2H-1,2-oxazin-3(4H)-one
CAS No. 127245-22-1
项目整合开发状态: Phase I
项目研究机构: Biofor (Originator)
合成路线:The 2,4-dibromobutyrylchloride (I) was reacted with N-methylhydroxylamine (II) in methylene chloride with NaOH to yield 4-bromo-2-methyl-5,6-dihydro-2H-1,2-oxazin-3(4H)-one (III).The reaction of (III) and zinc with 3,5-di-tert-butyl-4-hydroxybenzaldehyde (IV) underwent Reformatsky-type reaction.Dehydration of the hydroxymethyl intermediate (V) in refluxing toluene with p-toluenesulfonic acid afforded BF-389.